منابع مشابه
Lamellipodial actin branches out
Many cell types, including fi broblasts and epithelial cells, move forward by forming an actin-rich membrane protrusion, called a lamellipodium, at the front of the cell. In the early 1990s, researchers thought that lamellipodial protrusion was driven by the polymerization of linear actin fi laments. In two JCB papers published in 1997 and 1999, however, Tatyana Svitkina and colleagues revealed...
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Actin branches out in yeast any of the same proteins control actin polymerization in budding yeast and mammalian cells. But budding yeast researchers—hampered by an emphasis on genetics and an inaccessible yeast cytoplasm dense with ribosomes and glycogen granules—have often lagged behind in providing structural descriptions based on electron microscopy (EM). This has fueled suspicions about wh...
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Several new findings point to novel functions for the Arp2/3 complex. The dendritic nucleation model that has been proposed to describe cell extension for locomotion may also be applicable to other actin-based processes.
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Starving tumors eat metabolic enzyme Xia et al. describe a way to force cancer cells to destroy a key metabolic enzyme they need to survive. Autophagy helps cancer cells survive the stressful environment inside a tumor. However, blocking the process doesn’t kill cancer cells, so researchers have been looking for a way to make cells vulnerable to autophagy shutdown. Xia et al. used an ovarian ca...
متن کاملGMFβ prunes actin branches
Migrating fi broblasts assemble a dendritic network of branched actin fi laments that drives the formation of a lamellipodial protrusion at their leading edge. Haynes et al. reveal that, like a topiarist guiding the growth of a tree, a protein called GMF " prunes " this actin network in order to guide the cell's migration towards certain directional cues (1). Branched actin networks form when ...
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ژورنال
عنوان ژورنال: Nature
سال: 1998
ISSN: 0028-0836,1476-4687
DOI: 10.1038/28039